Kliovance is a medicine used in hormone replacement therapy. It is also useful in preventing osteoporosis in women following menopause as well as protecting against endometrial cancer, in women with an intact uterus.
During menopause, levels of oestrogen become low which can lead to symptoms such as hot flashes, night sweats, and dryness of the vagina, headaches, mood swings and lack of concentration as well as loss of energy. To relieve these symptoms, hormone replacement therapy uses two hormones: estradiol which is an oestrogen hormone and norethisterone acetate which is a progestogen hormone.

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How does Kliovance work?

The synthetic oestrogen identical to endogenous human oestradiol substitutes for the loss of oestrogen production during the menopause. Oestrogen has several other important actions in metabolic processes including fat metabolism and maintaining bone mass. Norethisterone is a synthetic copy of the hormone progesterone which closely resembles naturally made progesterone, and works in a similar way.

Progesterone acts on the lining of the uterus converting the proliferating phase to the secretory phase. The Norethisterone in Kliovance tablets prevents excess growth of the endometrium in response to the oestrogens present in Kliovance tablets which helps prevent endometrial cancer.

Kliovance contains estradiol and norethisterone acetate medicines. This type of HRT is more suitable for women whose menstrual cycle has already ceased. It does not produce a withdrawal bleed. Oestrogen may be used in the first year after the menopause and Kliovance may be used thereafter.

How do I take Kliovance?

Kliovance tablets should be taken once daily with a glass of water, at the same time each day, with or without food. A 28 tablet pack is one month’s treatment. Start a new pack the day after you finish one pack without a break. Continue to take Kliovance until the symptoms improve or as long as your doctor recommends. If you miss a dose of Kliovance take it as soon as you remember, or wait for the next due dose. Never take a double dose.

Does Kliovance have any side effects?

Most side-effects may only be a mild inconvenience, whilst other less common side-effects may be serious. Some of the side effects include; vaginal bleeding between menstrual periods, (other than within the first few months of starting treatment, or if you forget to take your tablet) If this continues after Kliovance has been taken for a long time or you have stopped taking it, seek medical advice.

Back pain, depression or worsening of depression, fluid retention, genital infections, irritation or inflammation of the vagina, bad headache, migraine or worsening of (seek immediate medical advice if you get a migraine for the first time), nausea, oedema of the extremities, uterine fibroids – uterine fibroids may worsen or return during treatment, weight gain.

How do I purchase Kliovance online?

First you must complete a short consultation online with the doctor when you buy Kliovance. This is a confidential process. Kliovance can be sent from the pharmacy to arrive to you the very next day once the online doctor has approved the treatment.

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